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Titre: Implantable Device for Monitoring Drugs and Metabolites in Small Animals for Applications in Personalized Medicine
Conférencier: Camilla Baj-Rossi , École polytechnique fédérale de Lausanne, Suisse
Lieu: École Polytechnique de Montréal, Pavillon Lassonde, M-2107 ,
Date et heure: lundi le 13 avril 2015 de 10:00 à 12:00

Résumé: The healthcare system and the pharmaceutical research are demanding high sensitive implantable devices for monitoring endogenous and exogenous metabolites to improve and personalize a therapy [1]. Small rodents are commonly used animals for developing new treatments and research applications. However, since the reduced size of mice, the implantable system has to be small, lightweight and biocompatible.
We realized a fully implantable device with a remote powering system, for monitoring glucose and drugs, in small animals. The device is a heterogeneous system that integrates the sensing platform, a coil to receive power [2], two custom-designed ASICs [3], one off-the-shelf micro-controller, and an antenna for data transmission to an android interface [2]. The implantable device hosts four electrochemical sensors, functionalized with nanomaterials and specific enzymes for drugs [4] and metabolites [5]. We developed a system of membrane to filter interfering substances and promote the biocompatibility.
We proved through an in-vitro characterization that the membrane retains enzyme activity up to 30 days, and in-vivo experiments in mice showed that after 30 days the packaging promotes the integration with the tissue. In-vitro calibrations and preliminary in-vivo tests in mice proved that the system can actively monitor glucose and the drug Paracetamol in real-time.

Note biographique: Camilla Baj-Rossi works as Ph.D. student in the Integrated System Laboratory (LSI), at the École polytechnique fédérale de Lausanne. Her research focuses on integrated systems based on electrochemical biosensors for the detection of endogenous metabolites and drugs in animals. She is interested in the entire process of biosensor development from the design and the fabrication of the sensor to the packaging and the validation of the device. She holds a Master degree in Biomedical Engineering and a Bachelor degree from Politecnico di Torino, Italy.


Références:
[1] Nichols, et al., Chemical Reviews, vol.113, pp.2528-2549, 2013.
[2] Kilinc, et al., IEEE TBCAS, vol.9, pp. 113 – 123, 2015.
[3] Ghoreishizadeh, et al., IEEE TBCAS, vol.8, pp. 891 – 898, 2014.
[4] Baj-Rossi, et al., Biosensors and Bioelectronics, vol.53, pp.283-287, 2014.
[5] Baj-Rossi, et al., IEEE TBCAS, vol.8, pp.636-647, 2014.

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