The objective of this research is to design innovative biomedical techniques and microsystems that exploit new ultra-low power circuit strategies, creative packaging methods, and state-of-the-art submicron CMOS manufacturing processes. Targeted applications include numerous portable and implantable medical technologies that will improve care and reduce healthcare costs, such as miniature platforms for cellular electrophysiological studies, high-performance rehabilitation aids, and detection and treatment systems targeting various neurological conditions. To stimulate the emergence of these new technologies, unique miniature devices combining wireless communication and biocompatible packaging are being created within a multidisciplinary framework spanning VLSI system design, electrophysiology, medical instrumentation, microfabrication techniques, and biology and neuroscience.